• Gram-Negative Bacteria Control: Effectively eliminates resistant strains including Pseudomonas, Coliforms, and E. coli.
• Yeast & Mold Reduction: Neutralizes fungal contaminants that compromise raw water quality.
• Comprehensive Disinfection: Provides broad-spectrum efficacy against protozoa and other microbial threats.

• Ozone’s powerful oxidative action breaks down organic impurities, lowering TOC levels in pharmaceutical raw water.
• Ensures cleaner, safer water for critical processes such as formulation, cleaning, and sterile manufacturing.

• Validated Performance: Proven efficacy in pharmaceutical-grade water systems.
• Sustainable & Chemical-Free: Harnesses ozone’s natural oxidizing power without harmful residues.
• Automation Ready: Seamlessly integrates with ultrafiltration, RO, UV, and micro-nano bubble systems for complete water treatment solutions.

Perfect — let’s enrich your website description with the technical mechanism of ozone on microbial cell walls, so it conveys both scientific credibility and practical impact for pharmaceutical water treatment. Here’s a refined section you can integrate:

Ozone (O₃) is one of the most powerful oxidizing agents used in water purification. Its antimicrobial efficacy comes from direct interaction with the cell walls and membranes of microorganisms:

• Oxidative Attack on Cell Walls: Ozone reacts with the double bonds of unsaturated fatty acids and glycoproteins in microbial cell walls. This disrupts the structural integrity of the membrane, leading to leakage of cellular contents and rapid cell death.

ram-negative bacteria are notoriously resistant due to their outer membrane of lipopolysaccharides and proteins. Ozone overcomes this barrier through:

• Cell Wall Oxidation: Ozone attacks unsaturated fatty acids and glycoproteins in the outer membrane, disrupting permeability and causing leakage.
• Enzyme Inactivation: Oxidizes sulfhydryl groups in enzymes, halting metabolism.
• Rapid Lysis: The oxidative stress leads to complete destruction of the bacterial cell structure.
• Broad-Spectrum Efficacy: Works against Pseudomonas, E. coli, Coliforms, and other Gram-negative pathogens, as well as yeast, mold, and protozoa.

Gram-negative bacteria such as Pseudomonas, Coliforms, and E. coli have an outer membrane rich in lipopolysaccharides. Ozone penetrates and oxidizes these components, making the cell wall permeable and non-functional.

Ozone oxidizes sulfhydryl (-SH) groups and amino acids in enzymes and proteins embedded in the cell wall. This halts essential metabolic processes, ensuring complete microbial inactivation.

Unlike chlorine or other disinfectants, ozone does not rely on selective pathways. Its oxidative mechanism is universal, making it effective against bacteria, yeast, mold, protozoa, and even resistant biofilm-forming organisms.

Unlike chlorine or other disinfectants, ozone does not rely on selective pathways. Its oxidative mechanism is universal, making it effective against bacteria, yeast, mold, protozoa, and even resistant biofilm-forming organisms.

Beyond microbial destruction, ozone breaks down complex organic molecules into simpler, biodegradable compounds. This reduces Total Organic Carbon (TOC), ensuring pharmaceutical water meets stringent purity standards.

• Rapid Disinfection: Instant microbial kill without long contact times.
• Residue-Free: Ozone decomposes back to oxygen, leaving no harmful by-products.
• Compliance Ready: Supports GMP and pharmacopeia standards for purified water systems.

• Contaminant Degradation: Ozone is specifically favored in pharmaceutical wastewater to eliminate "recalcitrant" pollutants, including active pharmaceutical ingredients (APIs), hormones, and antibiotics that chlorine cannot easily break down.
• Material Integrity: Ozone is generally less corrosive to stainless steel infrastructure common in pharma plants compared to the high-salinity or acidic environments chlorine can create.
• On-Site Generation: Ozone is produced as needed from ambient air or oxygen, eliminating the need for hazardous chemical storage or transportation (e.g., chlorine gas cylinders).
• Taste and Odor: Ozone removes organic-driven odors and tastes without introducing the "chemical" scent associated with chlorination.

• Pseudomonas species: Including P. aeruginosa (found in ~32% of samples), P. picketti(now Ralstonia picketti), P. vesiculares, and P. fluorescens.
• Ralstonia species: Particularly R. mannitolilytica and R. solanacearum, known for persisting in highly purified water.
• Sphingomonas species: Frequently identified during out-of-alert limit excursions in purified water systems.
• Other isolates: Acinetobacter lwoffi, Burkholderia cepacia, Flavobacterium aureum, and Stenotrophomonas maltophilia.

• Mechanism of Action: Ozone eliminates bacteria through protoplasmic oxidation, causing cell wall disintegration (cell lysis) and bypassing common antibiotic resistance mechanisms.
• Broad-Spectrum Efficacy: Achieves high log reductions (3-log to 6-log) in pathogens such as E. coli and Salmonella Typhimurium at low concentrations.
• Comparison to Chlorine: Ozone can achieve a 99% reduction of P. aeruginosa at concentrations as low as 0.4 ppm, whereas chlorine requires higher doses and longer CT values.
• Biofilm Destruction: Penetrates and breaks down the exopolysaccharide (EPS) matrix of biofilms that are highly resistant to chlorine.
• Antibiotic Resistance Control: Inactivates antibiotic-resistant bacteria (ARB) and reduces or removes antibiotic resistance genes (ARGs).

• Concentration & Time (CT): Effectiveness is dose-dependent; higher concentrations or longer contact times increase microbial mortality.
• Temperature & Humidity: Gaseous ozone performs optimally at lower temperatures and higher humidity levels.
• Water Quality: Elevated TSS or dissolved organic matter consumes ozone rapidly, requiring dosage optimization.

• DeBru Ozone safeguards pharmaceutical processes while supporting eco-friendly operations by reducing chemical dependency and improving water system efficiency.

• Superior microbial kill rate across bacteria, fungi, and protozoa.
• No harmful chemical residues or disinfection by-products.
• Effective TOC reduction to meet pharmaceutical water purity standards.
• Eco-friendly and sustainable, decomposing safely back into oxygen.